This Bisquick Chicken Alfredo Casserole with tomatoes and spinach is the perfect weeknight dinner! It’s made with simple ingredients and is ready in under one hour. A favorite easy, family-friendly recipe!
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I created this chicken casserole several months ago and it has quickly become a family favorite!
It starts with an easy Bisquick crust that is topped with layers of chicken, diced tomatoes and spinach and finally creamy Alfredo sauce. So simple, but so delicious!
Watch Video: Learn how to make this recipe
Ingredients for Bisquick Chicken Alfredo Casserole
- Bisquick. Any variety of plain Bisquick should work fine, even gluten-free. I personally like to use my homemade Bisquick Mix. It’s cheaper and I know exactly what ingredients are in it!
- Cooked Chicken. You can use whatever cooked chicken you have on hand…thighs, breasts, rotisserie. They’ll all be delicious.
- Alfredo Sauce. I love to use my homemade Alfredo sauce.
- Diced Tomatoes. I always use plain diced tomatoes, but I’m sure fire-roasted would be delicious too. You could even use Rotel if you enjoy a little heat.
- Fresh Spinach. You don’t have to add this but it’s an easy way to get more veggies into your diet. And it subtle enough that even my non-spinach-loving kids don’t mind it in this dish. If you like spinach, feel free to add more than the recipe calls for.
How to make this Bisquick Chicken Casserole
STEP ONE: Combine the Bisquick and water to form a soft dough. With your hands, press the dough into the bottom of a greased 8×8 or similar-sized baking dish.
The dough will be a bit sticky but making your hands slightly damp before spreading out the dough makes it much easier!
STEP TWO: Layer the cooked chicken, drained tomatoes and spinach on top of the crust, then top it all with Alfredo sauce. If you want, you can garnish the top with parsley.
STEP THREE: Bake at 375º for 25 to 30 minutes. Enjoy!
FAQ & Expert Tips
- Do I have to use cooked chicken? Yes. It will take a little longer to prep the recipe, but if you only have raw chicken on hand, you can always just cook some up. According to Taste of Home, ¾ lb. of raw chicken equals about 2 cups of cooked cubed chicken. This recipe calls for 1 ½ cups chicken so you may want to cook up a little less than ¾ lb.
- Can I use fresh tomatoes instead of canned ones? Yes, it should be fine. Just add 1 ¾ of freshly diced tomatoes instead.
- Do I have to add the spinach? No. This casserole is still delicious without it.
- Can this casserole be made ahead? I haven’t ever done it and wouldn’t recommend making it more than an hour ahead of time because the moisture of the Alfredo sauce and tomatoes may “leak” down onto the crust and keep it from baking properly.
More Casserole Recipes You’ll Love
- Easy Bisquick Chicken Pot Pie Casserole
- Easy John Wayne Casserole
- Cheesy Ham, Green Beans and Potatoes Casserole
- Hamburger Zucchini Bake
- Cheeseburger Casserole
- Oven Ready Lasagna (no-boil!)
Bisquick Chicken Alfredo Casserole
- 1 cup Bisquick mix (I use my homemade Bisquick)
- 1/4 cup cold water
- 1 1/2 cups cooked chicken, diced
- 1 1/4 cups Alfredo sauce (I use my easy homemade Alfredo)
- 1 can (14.5 oz.) diced tomatoes, drained
- 1/2 cup fresh spinach, chopped and lightly packed (optional)
- parsley, for garnish (optional)
- Combine Bisquick and water to form a soft dough. With your hands, press the dough into the bottom of a greased 8×8 or similar sized baking dish. It helps to make your hands slightly damp to do this.
- Layer the cooked meat, drained tomatoes and spinach on top of the crust. Top with Alfredo sauce and garnish with parsley if desired.
- Bake at 375° for 25 to 30 minutes.
- Only have raw chicken on hand? Try cooking up approximately ¾ lb. boneless chicken breasts or things. It should give you close to the 1 ½ cups you need.
- If you prefer using fresh tomatoes, you can substitute 1 ¾ cups diced fresh tomatoes for the canned tomatoes.
I am making this next week so excited.
I hope you enjoy it! It’s simple but we think it’s very comforting and tasty.
I, too, am making this for dinner!
Yay! I hope you enjoyed it, Sandy!
Could diced broccoli florets be used in lieu of, or combined with the tomatoes? This dish sounds amazing, but unfortunately the kiddos are against anything with tomatoes.
You could probably add the broccoli with the tomatoes (you may want to steam it first?), but I don’t think it would work to totally leave out the tomatoes because I think the final dish would be too dry. My kids aren’t big tomato fans either but they don’t mind them in this dish. One thing that I have found that helps is if I drain the tomatoes using a sieve and then while they are still in the sieve, I take scissors and cut up the tomatoes into smaller pieces. In fact, it almost mashes them or makes it more like pasta sauce, which my kids like. I think it’s more the chunky, firmer texture that they don’t care for. Not sure if that would help your kiddos or not?
I’m just curious Lydia. In the printable recipe there’s an item listed as “Cook Mode” followed by the words “Prevent your screen from going dark.” Is this something we need to know about because I have no idea what it means! Other than that, this recipe sounds delicious and I’m making it for dinner tomorrow.
Hi Pat! That is a feature that the creator of the recipe card recently added. It’s for people that are wanting to make the recipe without printing it out. They can toggle the button and it prevents the computer/tablet/phone screen from going dark while they are on that page, which is quite handy since it’s really annoying to have to keep having your screen go dark while needing to reference it. I don’t know why it’s called “Cook Mode” though as I can see how it can sound a bit like it’s something related to how you are to prepare the recipe! All that to say, you don’t need to worry about it if you are printing out the recipe. And I hope you all enjoy it as much as we have!