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4.94 from 29 votes

John Wayne Casserole

This easy recipe combines layers of sour cream, cheese, tomatoes and ground beef on top of a tasty Bisquick crust for a delicious kid friendly dinner!  
Prep Time15 minutes
Cook Time30 minutes
Total Time45 minutes
Course: Main Course
Cuisine: American
Servings: 5 people
Author: Lydia @ ThriftyFrugalMom.com


  • ½ lb. ground beef
  • 2 Tbsp. onion, chopped
  • ½  c. sour cream
  • ¼  c. mayonnaise
  • ½  c. shredded cheddar cheese
  • ¼  tsp. garlic powder (see recipe notes)
  • 1 c. Bisquick (link to homemade Bisquick in recipe notes below)
  • ¼  c. cold water
  • 2 tomatoes, diced- more if preferred (see recipe notes)
  • paprika optional


  • Brown ground beef and onion.
  • Mix sour cream, mayonnaise, cheese and garlic powder.  Set aside.
  • Combine Bisquick and water to form soft dough.  Press into the bottom of a greased 8×8 baking dish.  (It helps to make your hands slightly damp to do this!)
  • Top with cooked ground beef then the tomatoes, then the sour cream mixture.  Sprinkle with paprika if desired.
  • Bake at 375° for 25 to 30 minutes.


  • Tomatoes: 1 (15 oz.) can of drained diced tomatoes can be subbed for the tomatoes- just be sure to drain them really well! 
  • I love using my Homemade Bisquick Mix recipe.
  • Garlic Powder: can substitute with 1 tsp. jarred minced garlic or 1/2 tsp. granulated garlic.
  • Doubling Recipe: You can easily double this and make it in a 9 x 13 baking dish instead.
  • Additions: feel free to add in corn, green chilis or peppers.  If adding peppers, fry them up with the ground beef and onion